Expanded AGS Beers Criteria offer new info, tools for safer medication use in older adults

The American Geriatrics Society (AGS) has released its second updated and expanded Beers Criteria–lists of potentially inappropriate medications for older adults who are not receiving hospice or palliative care, and one of the most frequently cited reference tools in the field of geriatrics. The Society also unveiled a suite of new companion resources–including a list of alternative therapies for potentially inappropriate medications and more detailed guidance on best practices for implementing AGS recommendations–all published online in the Journal of the ...

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Mapping the genes that increase lifespan

Comprehensive study finds 238 genes that affect aging in yeast cells

Following an exhaustive, ten-year effort, scientists at the Buck Institute for Research on Aging and the University of Washington have identified 238 genes that, when removed, increase the replicative lifespan of S. cerevisiae yeast cells. This is the first time 189 of these genes have been linked to aging. These results provide new genomic targets that could eventually be used to improve human health. The research was published online on ...

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Smoking and heavy alcohol use are associated with epigenetic signs of aging

Cigarette smoking and heavy alcohol use cause epigenetic changes to DNA that reflect accelerated biological aging in distinct, measurable ways, according to research presented at the American Society of Human Genetics (ASHG) 2015 Annual Meeting in Baltimore.

Using data from the publicly available Gene Expression Omnibus, Robert A. Philibert, MD, PhD and colleagues at the University of Iowa and other institutions analyzed patterns of DNA methylation, a molecular modification to DNA that affects when and how strongly a gene is expressed. ...

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Diet supplement keeps circadian clock from slowing down in aging mice

Falling levels of polyamines, compounds present in all living cells, cause circadian rhythms to slow down in older mice, reports a study published October 8 in Cell Metabolism. This effect was reversed by dietary supplementation with a type of polyamine called spermidine, which is abundant in foods such as soybeans, corn, green peas, and blue cheese. No studies have yet been conducted in humans.

“This discovery demonstrates the tight intertwining between circadian clocks and metabolism and opens new possibilities for nutritional ...

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Depression: not a normal part of aging

Health problems, reduced income and the death or a partner or loved one are just some of the difficulties often faced in older age. With this in mind, it is perhaps unsurprising that around 7 million American adults aged 65 and older experience some form of depression. What is surprising is that depression among seniors is often overlooked and untreated.
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Around 7 million adults aged 65 and older in the US have ...
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Big Marijuana Reforms Included in Senate Spending Package

A key Senate leader has included several pieces of good news for marijuana law reform advocates in a package of spending bills intended to keep the government operational for the next fiscal year.

Sen. Thad Cochran (R-MS), chairman of the Appropriations Committee, filed the bills on Tuesday, and they have just been uploaded to Congress’s website.

Here’s what the bills’ language will do, if enacted:

* Prevent the Department of Justice and the Drug Enforcement Administration from spending money ...

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Ohio Marijuana Legalization Could Bring Comprehensive Research And Medical Marijuana Insurance

Provided Ohio’s Issue 3 passes on November 3rd, a new not-for-profit marijuana research facility is prepared to pony up approximately $24 million to build a state-of-the-art research facility.

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Announced earlier this week, the International Cannabinoid Institute has let it be known that it will rent land near Columbus from the same investors backing the marijuana ...

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CNIO researchers have discovered a new player in tumor suppression and aging

A study conducted by the Spanish National Cancer Research Centre´s (CNIO) Genomic Instability Group, led by Oscar Fernández-Capetillo, describes for the first time in mammals, the role played by the SMC5/6 protein complex in cancer suppression and premature ageing. Mutations in these complexes, which were sensitive to chemotherapeutic agents, had been previously described in yeast cells, but their exact relationship with cancer or other diseases in mammals was unknown. Researchers from the CNIO´s Telomere and ...

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Marijuana Policy Impacts FBI’s Cybercrime Fight

Current hiring rules at the Federal Bureau of Investigation (FBI) prevent the agency from offering a job to anyone who has used marijuana within the past three years. And that has an impact on the federal government’s ability to recruit talented hackers to wage the increasingly prominent fight against cybercrime by virtue of the fact that many coders are also cannabis enthusiasts.

But there are signs that the FBI may be coming to terms with the fact that the ...

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